Project

The amyloid precursor protein (APP) is the source of amyloid-beta (Abeta), the small protein whose abnormal deposition in the brain is thought to cause Alzheimer's disease. But APP's normal role has remained elusive, despite years of study. Our group is interested in elucidating the cellular function of the amyloid precursor protein (APP) in health and disease.

Related Publications

• Konietzko U, Goodger ZV, Meyer M, Kohli BM, Bosset J, Lahiri DK, Nitsch RM (2008) Co-localization of the amyloid precursor protein and Notch intracellular domains in nuclear transcription factories Neurobiol Aging.
• Kuehnle K, Crameri A, Kälin RE, Luciani P, Benvenuti S, Peri A, Ratti F, Rodolfo M, Kulic L, Heppner FL, Nitsch RM, Mohajeri MH (2008) Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Mol Cell Biol. 28(2):539-50.
• Knobloch M, Farinelli M, Konietzko U, Nitsch RM, Mansuy IM. (2007) Abeta oligomer-mediated long-term potentiation impairment involves protein phosphatase 1-dependent mechanisms. J Neurosci. 18;27(29):7648-53.
• Kohli BM, Eng JK, Nitsch RM, Konietzko, U (2005) An alternative sampling algorithm for use in liquid chromatography/tandem mass spectroscopy experiments. Rapid Commun. Mass Spectrom. 19, 589-96.
• von Rotz RC, Kohli BM, Bosset J, Meier M, Suzuki T, Nitsch RM, Konietzko U (2004) The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor. J. Cell Sci. 117, 4435-4448.